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Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus

S Kralisch, University of Leipzig, Leipzig, Germany
H Stepan, University of Leipzig, Leipzig, Germany
J Kratzsch, University of Leipzig, Leipzig, Germany
M Verlohren, Outpatient Care Unit, Leipzig, Germany
H Verlohren, Outpatient Care Unit, Leipzig, Germany
K Drynda, Outpatient Care Unit, Leipzig, Germany
U Lossner, Leipzig, Germany
M Bluher, University of Leipzig, Leipzig, Germany
M Stumvoll, University of Leipzig, Leipzig, Germany
M Fasshauer, Leipzig, Germany

Correspondence: Mathias Fasshauer, Email: mathias.fasshauer{at}medizin.uni-leipzig.de

Abstract

Objective: Adipocyte fatty acid binding protein (AFABP) was recently introduced as a novel adipokine, serum levels of which independently correlate with the development of the metabolic syndrome and cardiovascular disease in humans. In the current study, we investigated serum concentrations of AFABP in patients with gestational diabetes mellitus (GDM) as compared to healthy pregnant controls matched for gestational age and fasting insulin.

Design and Methods: AFABP was determined by ELISA in control (n=80) and GDM (n=40) patients and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation, in both groups.

Results: Median serum AFABP concentrations were significantly elevated in subjects with GDM (22.9 µg/l) as compared to healthy pregnant controls (18.3 µg/l) (p < 0.05). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis (p < 0.05). In addition, markers of adiposity (body mass index, serum leptin), triglycerides, and serum creatinine were independently associated with circulating AFABP (p < 0.05).

Conclusions: Maternal AFABP concentrations are significantly increased in GDM. The adipokine might contribute to the increased metabolic and cardiovascular risk of the disease.