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Mortality from thyroid cancer in patients with hyperthyroidism: The Theagenion Cancer Hospital experience

K Pazaitou-Panayiotou, Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, Thessaloniki, 54007, Greece
P Perros, Department of Endocrinology, Freeman Hospital, Newcastle upon Tyne, UK, Newcastle upon Tyne, United Kingdom
M Boudina, Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, Thessaloniki, Greece
G Siardos, Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, Thessaloniki, Greece
A Drimonitis, Department of Endocrinology-Endocrine Oncology, Theagenio Cancer Hospital, Thessaloniki, Greece
F Patakiouta, Department of Pathology, Theagenio Cancer Hospital, Thessaloniki, Greece
I Vainas, Thessaloniki, Greece

Correspondence: Kalliopi Pazaitou-Panayiotou, Email: kpazaitou{at}in.gr

Abstract

Abstract

Background: Thyroid carcinoma has been reported in patients operated for different types of hyperthyroidism and the probability of a hot nodule being malignant seems to be low. The aim of the present study was to explore the relationship between thyroid cancer, hyperthyroid-ism and outcome in a large cohort of patients who presented to a tertiary cancer centre in Northern Greece. Patients: Among 720 patients treated for thyroid cancer, 60 had a concomi-tant diagnosis of hyperthyroidism due to Graves disease (n=14), solitary autonomous ade-noma (n=17), or multinodular goiter (n=29). Adverse prognostic factors were common in pa-tients with a previous history of hyperthyroidism at the time of diagnosis of thyroid cancer, including cases where the cancer was discovered coincidentally after thyroid surgery for hy-perthyroidism and cases where tumor size was >10mm. Results: In 10 of 17 patients with hy-perthyroidism due to solitary autonomous adenomas, the tumor was located within the hot nodule and two of these patients developed local and distant metastases and died from the disease 4 and 15 years after thyroidectomy. Conclusion: Clinicians managing patients with hyperthyroidism need to be aware of the possible increased risk of thyroid cancer in this pa-tient group.