HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Accepted manuscript (PDF) All Versions of this Article: EJE-08-0201v1 159/4/389    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Colao, A. Articles by Savastano, S. PubMed PubMed Citation Articles by Colao, A. Articles by Savastano, S.

Relationships between serum insulin-like growth factor-I levels, blood pressure and glucose tolerance: an observational, exploratory study in 404 subjects

A Colao, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, 80131, Italy
C Di Somma, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
T Cascella, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
R Pivonello, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
G Vitale, Milan, Italy
L Grasso, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
G Lombardi, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy
S Savastano, Molecular and Clinical Endocrinology and Oncology, University Federico II of Naples, Naples, Italy

Correspondence: Annamaria Colao, Email: colao{at}unina.it

Abstract

Background: In the general population, low IGF-I has been associated with higher prevalence of cardiovascular disease and mortality.

Objective: To investigate the relationships between IGF-I levels, blood pressure (BP) and glucose tolerance (GT).

Subjects: 404 subjects (200 men 18-80 yrs aged). Exclusion criteria: personal history of pituitary or cardiovascular diseases; previous or current treatments with drugs interfering with BP, GT, or lipids, corticosteroids (>2 weeks), estrogens or testosterone (>12 weeks); smoking of >15 cigarettes/day and alcohol abuse (>3 glasses of wine/day).

Results: 296 had normal BP (73.3%), 86 had mild (21.3) and 22 had severe hypertension (5.4%); 322 had normal GT [NGT (79.7%)], 53 had impaired fasting glucose [IGT (13.1%)], 29 had diabetes mellitus (7.2%). Normotensive subjects had significantly higher IGF-I levels (0.11±0.94 SDS) than those with mild (-0.62±1.16 SDS, p<0.0001) or severe hypertension (-1.01±1.07 SDS, p<0.0001). IGF-I SDS (t=-3.41, p=0.001) independently predicted systolic and diastolic BP (t=-2.77, p=0.006). NGT subjects had significantly higher IGF-I levels (0.13±0.90 SDS) than those with IGT (-0.86±1.14 SDS, p<0.0001) or diabetes mellitus (-1.31±1.13 SDS, p<0.0001). IGF-I SDS independently predicted fasting glucose (t=-3.49, p=0.0005) and HOMA-R (t=-2.15, p=0.033) but not insulin (t=-1.92, p=0.055) and HOMA-β (t=-0.19, p=0.85).

Conclusion: IGF-I levels in the low normal range is associated with hypertension and diabetes in subjects without pituitary and cardiovascular diseases.