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Incidence of hyperthyroidism in Stockholm, Sweden, 2003–2005.

Division of Surgery, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, SE-17176 Stockholm, Sweden¹ Department of Clinical Research and Education Sodersjukhuset, Karolinska Institutet, Sodersjukhuset, SE-11883 Stockholm, Sweden² Division of Endocrinology,, Department of Internal Medicine, Sodersjukhuset, SE-11883 Stockholm, Sweden³ Department of Endocrinology,, Malmö University Hospital, SE-21420 Malmö, Sweden⁴ Department of Oncology,, Karolinska University Hospital, SE-17176 Solna, Sweden⁵ Department of Endocrinology,, Metabolism and Diabetes, Karolinska University Hospital, Karolinska Institutet, SE-17176 Stockholm, Sweden⁶ Department of Clinical Sciences,, Karolinska Institutet, SE-17177 Stockholm, Sweden and ⁷ Department of Medicine,, Danderyd Hospital, SE-18288 Stockholm, Sweden

(Correspondence should be addressed to M Abraham-Nordling; Email: mirna.nordling{at}ds.se)

Objectives: To investigate the incidence of hyperthyroidism in Stockholm County, in those patients who were diagnosed with hyperthyroidism for the first time during the years 2003–2005.

Design: All new cases of hyperthyroidism 18 years of age were prospectively registered to calculate the total incidence of hyperthyroidism, as well as the incidence of the subgroups: Graves' disease (GD), toxic multinodular goitre and solitary toxic adenoma (STA). Eight specialized units/hospitals in Stockholm County participated in the registration. The participating physicians were all specialists in medical endocrinology, oncology, nuclear medicine or surgery.

Results: During a 3-year period, 1431 new patients of hyperthyroidism were diagnosed in a well-defined adult population (>18 years of age) of in average 1 457 036 inhabitants. This corresponds to a mean annual incidence of hyperthyroidism of 32.7/100 000. The incidence of GD was 24.5/100 000 per year, toxic nodular goitre was 3.3/100 000 per year and STA was 4.9/100 000 per year.

Conclusions: The total incidence of hyperthyroidism in Stockholm County was found to be 32.7/100 000 per year, of which 75% had GD. There were a higher percentage of smokers among the patients with hyperthyroidism compared with the overall population in Stockholm, but no difference in the frequency of smoking between patients with GD and toxic nodular goitre.