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A case of constrictive pericarditis during cabergoline treatment for hyperprolactinaemia.

Department of Endocrinology, Lund University Hospital, S-221 85 Lund, Sweden¹ Department of Internal Medicine, Angelholm Hospital, Angelholm, Sweden² Department of Radiology, Helsingborg Hospital, Helsingborg, Sweden

(Correspondence should be addressed to M Löndahl; Email: magnus.londahl{at}skane.se)

Abstract

Objective: Treatment with dopamine agonists has been associated with cardiopulmonary fibrotic reactions, predominantly in patients treated for Parkinson's disease. To our knowledge, these reactions have previously not been associated with low-dose cabergoline treatment for hyperprolactinaemia.

Method: A case of constrictive pericarditis in a patient treated with cabergoline for hyperprolactinaemia is presented. The patient has been treated at a county hospital and a university hospital in southern Sweden.

Results: A 20-year-old woman with a 3-year history of amenorrhoea was referred to the department in 1992. From 2001 to 2005, she was given cabergoline, 0.5–1.5 mg/week. In 2005 a pericardectomy was performed due to fibrotic, constrictive pericarditis.

Conclusions: Our present case suggests that constrictive pericarditis may develop even on low-dose cabergoline, which might indicate that this reaction, as opposed to valvular fibrosis, is not mediated by a 5-HT_2B agonistic mechanism.