Eur J Endocrinol
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DOI: 10.1530/EJE-07-0163
European Journal of Endocrinology, Vol 157, suppl_1, S47-S50
Copyright © 2007 by European Society of Endocrinology
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ARTICLE

Metabolic implications of GH treatment in small for gestational age

E M Delemarre, J Rotteveel1 and H A Delemarre-van de Waal1

Medical School Leiden University Medical Center, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands and 1 Department of Pediatric Endocrinology and Institute of Clinical and Experimental Neurosciences, VU University Medical Center, PO Box 7057, 1007 Amsterdam, The Netherlands

(Correspondence should be addressed to H A Delemarre-van de Waal; Email: h.delemarre{at}vumc.nl)

This paper was presented at the Ipsen symposium, ‘The evolving biology of growth and metabolism’, Lisbon, Portugal, 16–18 March 2007. Ipsen has supported the publication of these proceedings.

Abstract

Fetal growth retardation is associated with decreased postnatal growth, resulting in a lower adult height. In addition, a low birth weight is associated with an increased risk of developing diseases during adulthood, such as insulin resistance, type 2 diabetes mellitus, hypertension, dyslipidemia, and cardiovascular diseases. Children with persistent postnatal growth retardation, i.e., incomplete catchup growth, can be treated with human GH. The GH/IGF-I axis is involved in the regulation of carbohydrate and lipid metabolism. The question of whether treatment with GH in children born small for gestational age (SGA) has long-term implications with respect to glucose/insulin and lipid metabolism has not been answered yet. In this article, the available data are reviewed.






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