HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (7) Citing Articles via Google Scholar Google Scholar Articles by Christ, E. R Articles by Décombaz, J. Search for Related Content PubMed PubMed Citation Articles by Christ, E. R Articles by Décombaz, J.

The effect of increased lipid intake on hormonal responses during aerobic exercise in endurance-trained men

Divisions of Endocrinology and Diabetes, ¹ Clinical Research and ² Paediatrics, University Hospital of Berne, Inselspital, CH-3010 Bern, Switzerland and ³ Nestlé Research Centre, Nestec Ltd, Lausanne, Switzerland

(Correspondence should be addressed to E R Christ; Email: emanuel.christ{at}insel.ch)

In view of the growing health problem associated with obesity, clarification of the regulation of energy homeostasis is important. Peripheral signals, such as ghrelin and leptin, have been shown to influence energy homeostasis. Nutrients and physical exercise, in turn, influence hormone levels. Data on the hormonal response to physical exercise (standardized negative energy balance) after high-fat (HF) or low-fat (LF) diet with identical carbohydrate intake are currently not available. The aim of the study was to investigate whether a short-term dietary intervention with HF and LF affects ghrelin and leptin levels and their modulators, GH, insulin and cortisol, before and during aerobic exercise. Eleven healthy, endurance-trained male athletes (W_max 365 ± 29 W) were investigated twice in a randomized crossover design following two types of diet: 1. LF – 0.5 g fat/kg body weight (BW) per day for 2.5 days; 2. HF – 0.5 g fat/kg BW per day for 1 day followed by 3.5 g fat/kg BW per day for 1.5 days. After a standardized carbohydrate snack in the morning, metabolites and hormones (GH, ghrelin, leptin, insulin and cortisol) were measured before and at regular intervals throughout a 3-h aerobic exercise test on a cycloergometer at 50% of W_max. Diet did not significantly affect GH and cortisol concentrations during exercise but resulted in a significant increase in ghrelin and decrease in leptin concentrations after LF compared with HF diet (area under the curve (AUC) ghrelin LF vs HF: P < 0.03; AUC leptin LF vs HF: P < 0.02, Wilcoxon rank test). These data suggest that acute negative energy balance induced by exercise elicits a hormonal response with opposite changes of ghrelin and leptin. In addition, the hormonal response is modulated by the preceding intake of fat.

This article has been cited by other articles:

				D. R. Broom, R. L. Batterham, J. A. King, and D. J. Stensel Influence of resistance and aerobic exercise on hunger, circulating levels of acylated ghrelin, and peptide YY in healthy males Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2009; 296(1): R29 - R35. [Abstract] [Full Text] [PDF]

				J. Jurimae, T. Jurimae, and P. Purge Plasma Ghrelin Is Altered After Maximal Exercise in Elite Male Rowers Experimental Biology and Medicine, July 1, 2007; 232(7): 904 - 909. [Abstract] [Full Text] [PDF]

				D. R. Broom, D. J. Stensel, N. C. Bishop, S. F. Burns, and M. Miyashita Exercise-induced suppression of acylated ghrelin in humans J Appl Physiol, June 1, 2007; 102(6): 2165 - 2171. [Abstract] [Full Text] [PDF]

				K. J. Mackelvie, G. S. Meneilly, D. Elahi, A. C. K. Wong, S. I. Barr, and J.-P. Chanoine Regulation of Appetite in Lean and Obese Adolescents after Exercise: Role of Acylated and Desacyl Ghrelin J. Clin. Endocrinol. Metab., February 1, 2007; 92(2): 648 - 654. [Abstract] [Full Text] [PDF]