Eur J Endocrinol
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DOI: 10.1530/eje.0.1510351
European Journal of Endocrinology, Vol 151, Issue 3, 351-354
Copyright © 2004 by European Society of Endocrinology
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Clinical Studies

Insulin sensitivity in Turner's syndrome: influence of GH treatment

G Radetti, B Pasquino, E Gottardi, I Boscolo Contadin, G Aimaretti, and F Rigon

Department of Paediatrics, Regional Hospital, via L. Boehler 5, 39100 Bolzano, Italy. giorgio.radetti@asbz.it

OBJECTIVE: Excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed individuals. Turner's syndrome (TS) patients are a population at risk since they have reduced glucose tolerance (GT) spontaneously and because they are usually treated with high doses of GH. DESIGN AND METHODS: The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of TS patients treated with GH for a period of 6 years. Forty-seven TS girls were included in the study. GH was administered at a mean weekly dosage of 0.35 mg/kg, injected subcutaneously over 6-7 days. GT was assessed according to the criteria of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. IS was evaluated with the quantitative insulin sensitivity check index (QUICK-I). RESULTS: No significant increase of impaired GT was observed in the patients during the follow-up period, while a reduced IS was detected. IS in TS patients was already lower than in prepubertal controls (P<0.001) before starting treatment and further decreased during the first year of therapy (P<0.05), and then remained stable over the following years. No correlation was found between QUICK-I, body mass index, years of treatment, onset and duration of puberty. One patient became diabetic during the course of treatment. CONCLUSIONS: GH treatment in TS girls does not significantly increase the prevalence of impaired GT or type 2 diabetes mellitus, while it does, however, decrease IS.


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N. Wooten, V. K. Bakalov, S. Hill, and C. A. Bondy
Reduced Abdominal Adiposity and Improved Glucose Tolerance in Growth Hormone-Treated Girls with Turner Syndrome
J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2109 - 2114.
[Abstract] [Full Text] [PDF]


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